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KMID : 0364820000360010064
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Korean Journal of Microbiology
2000 Volume.36 No. 1 p.64 ~ p.68
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Immunopotentiatiing Effect of Polysaccharides Extracted from Agrocybe cylindracea
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Kim Seon-Hee
Lee Hang-Woo
Bae Man-Jong
Lee Jae-Sung
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Abstract
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The immunopotentiating effects of the polysaccharides, both intracellular and extracellular, was examined by an animal feeding test. The results are summarized as follows. The oral administration of intracellular and extracellular polysaccharides of Agrocybe cylindracea for 10 days resulted in the enhanced phagocytic activity of peritoneal exudate cells(PEC), spleen cells(SC), and monolymphocytes(ML). In the experiment of PFC(plaque forming cell) ad RFC(rosette forming cell), the results showed that all the polysaccharide fractions enhanced the immune related cells. The EAC Ⅱ group(the extracellular polysaccharide of Agrocybe cylindracea 10 ㎎/0.2 ㎖ distilled water/day/mouse) increased the PFC and RFC by 46∼50% and 43%, respectively, compared to the cotrol group. On the other hand, the IAC Ⅰ group(the intracellular polysaccharide of Agrocybe cylindracea 1 ㎎/0.2 ㎖ distilled water/day/mouse) increased the PFC and RFC by 49∼70% and 91%, respectively. In terms of the mitogenic activity, the extracellular polysaccharides of A. cylindracea showed a higher activity than the intracellular polysaccharides.
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KEYWORD
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Agrocybe cylindracea, Mitogen activity, Plaque forming cell, Rosette forming cell,
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